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Users of Option B versions up to version 6.03 who have Excel 2010 may see a “Macros are disabled” warning in the header area of the spreadsheet.  When an Option B workbook is opened, a macro runs that reads some identity information from the Control Center and hides the red “Macros are disabled” warning in the header area of the spreadsheet. In Excel 2010 only (not in earlier versions of Excel), this macro runs only if Excel is already running when you open the workbook.

Therefore for Excel 2010 and Option B versions prior to 6.1, we strongly recommend that you start Excel 2010 before opening an Option B workbook.